Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) Antibody (FITC)
429€ (100 µg)
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935106861
info@markelab.com
name
Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx414236
tested applications
FCM
Description
Programmed Cell Death 1 Ligand 2 (CD273) Antibody (FITC) is a Rat Monoclonal antibody against Programmed Cell Death 1 Ligand 2 (CD273).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) |
| Host | Rat |
| Reactivity | Mouse |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | FITC |
| Isotype | IgG2a |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | PBS, 1% BSA. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9WUL5 |
| Alias | B7DC,Btdc,PDL2,CD273,PD-L2,PDCD1L2,PD-1 ligand 2,PDCD1 ligand 2,Butyrophilin B7-DC,B7-DC |
| Background | Antibody anti-PDCD1LG2 |
| Status | RUO |
| Note | Concentration: 0.1 mg/ml - |
Descripción
Programmed cell death 1 ligand 2 (PDCD1LG2), commonly referred to as PD-L2, is an immune regulatory protein that belongs to the B7 family of immune checkpoint ligands. PD-L2 functions as a ligand for PD-1 (Programmed Cell Death Protein 1), an inhibitory receptor on T cells, and contributes to the modulation of immune responses by promoting T cell inhibition. This ligand is highly relevant in immune tolerance, particularly in peripheral tissues where it helps prevent excessive immune reactions that could lead to tissue damage. PD-L2, together with its better-known counterpart PD-L1, plays a key role in immune escape mechanisms in cancers, where it inhibits T cell activation and proliferation, enabling tumor cells to evade immune surveillance. PD-L2 is selectively expressed on antigen-presenting cells (APCs) such as dendritic cells (DCs), macrophages, and B cells. Its expression is inducible, being upregulated under conditions of inflammation or during immune activation through signals like interleukin-4 (IL-4) and interferon-gamma (IFN-γ). This selective and inducible expression of PD-L2 suggests it has specialized roles in fine-tuning immune responses, distinguishing it from PD-L1, which is more broadly expressed across various cell types, including non-immune cells.
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