Programmed cell death 1 ligand 2 (PDCD1LG2) Antibody
299€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Programmed cell death 1 ligand 2 (PDCD1LG2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx341060
tested applications
ELISA, WB, IHC, IF/ICC, FCM, IP
Description
Programmed cell death 1 ligand 2 (PDCD1LG2) Antibody is a Mouse Monoclonal antibody for the detection of Human PD-L2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Programmed cell death 1 ligand 2 (PDCD1LG2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Purity | > 95% |
| Purification | Purified by Protein A chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM, IP |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BQ51 |
| Gene ID | 80380 |
| Alias | B7DC,Btdc,PDL2,CD273,PD-L2,PDCD1L2,PD-1 ligand 2,PDCD1 ligand 2,Butyrophilin B7-DC,B7-DC |
| Background | Antibody anti-PDCD1LG2 |
| Status | RUO |
Descripción
Programmed cell death 1 ligand 2 (PDCD1LG2), commonly referred to as PD-L2, is an immune regulatory protein that belongs to the B7 family of immune checkpoint ligands. PD-L2 functions as a ligand for PD-1 (Programmed Cell Death Protein 1), an inhibitory receptor on T cells, and contributes to the modulation of immune responses by promoting T cell inhibition. This ligand is highly relevant in immune tolerance, particularly in peripheral tissues where it helps prevent excessive immune reactions that could lead to tissue damage. PD-L2, together with its better-known counterpart PD-L1, plays a key role in immune escape mechanisms in cancers, where it inhibits T cell activation and proliferation, enabling tumor cells to evade immune surveillance. PD-L2 is selectively expressed on antigen-presenting cells (APCs) such as dendritic cells (DCs), macrophages, and B cells. Its expression is inducible, being upregulated under conditions of inflammation or during immune activation through signals like interleukin-4 (IL-4) and interferon-gamma (IFN-γ). This selective and inducible expression of PD-L2 suggests it has specialized roles in fine-tuning immune responses, distinguishing it from PD-L1, which is more broadly expressed across various cell types, including non-immune cells.
Related Products
Human PDCD1LG2(Programmed Cell Death Protein 1 Ligand 2) ELISA Kit
Ver Producto
Rat PDCD1LG2(Programmed Cell Death Protein 1 Ligand 2) ELISA Kit
Ver Producto
Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) Antibody
PDCD1LG2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Ver Producto