935106861
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Precio
1575€ (5 × 96 tests)
Prion Protein (PRNP) Antibody Pair for use in Sandwich ELISA assay development. This antibody pair contains: Component 5 × 96 tests 10 × 96 tests Capture Antibody200 µg 400 µg Biotin-Conjugated Detection Antibody 50 µg 100 µg Standard 2 µg 10 µg Please note that quantities and concentrations may change between different batches. It is recommended to use this antibody pair with abx098958 Antibody Pair Support Kit (Sandwich Method).
The PRNP gene, encoding the prion protein (PrP), plays a critical role in both neurobiology and disease. This gene is located on chromosome 20 in humans and encodes the cellular prion protein, PrP^C. Prion proteins are unique in their ability to exist in multiple conformations, including a pathological form, PrP^Sc, associated with prion diseases. Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are neurodegenerative disorders marked by rapidly progressive neuronal loss and a spongiform appearance in brain tissue. TSEs include diseases such as Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gerstmann-Sträussler-Scheinker syndrome (GSS), and kuru. The prion protein (PrP) is primarily expressed in the central nervous system (CNS), especially in neurons, but it is also found in other tissues. While the physiological function of PrP^C remains partially understood, it is thought to be involved in cellular processes like cell signaling, protection against oxidative stress, and synaptic function. Its pathological form, PrP^Sc, is formed by a misfolded conformation of PrP^C that becomes self-propagating, causing other normal PrP^C molecules to misfold. This cascade leads to the accumulation of toxic aggregates and extensive neuronal damage, a hallmark of prion diseases.
Primary Antibodies
Rat
Prion Protein (PRNP)
Liquid (Capture Antibody and Detection Antibody)
ELISA
The Capture and Detection Antibody both contain 0.1% sodium azide.
5 × 96 tests
10 × 96 tests
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
PRNP
No
Please enquire.
Creutzfeldt-Jakob disease,CJD,GSS,PrP,ASCR,KURU,PRIP,PrPc,CD230,Alternative prion protein
This product is for research use only.
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