Presenilin 1 (PSEN1) Antibody (FITC)
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Description
PSEN1 Antibody (FITC) is a Rabbit Polyclonal against PSEN1 conjugated to FITC.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Presenilin 1 (PSEN1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49768 |
| Gene ID | 5663 |
| NCBI Accession | NP_000012.1, NM_000021.3 |
| OMIM | 104311 |
| Background | Antibody anti-PSEN1 |
| Status | RUO |
Descripción
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Presenilin 1 (PSEN1) Antibody
PSEN1 Antibody is a Rabbit Polyclonal antibody against PSEN1. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
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