Pregnancy Associated Plasma Protein A (PAPP-A) Antibody
949€ (1 mg)
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935106861
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name
Pregnancy Associated Plasma Protein A (PAPP-A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx024046
tested applications
ELISA
Description
Pregnancy Associated Plasma Protein A (PAPP-A) Antibody is a Cell Culture Monoclonal against Pregnancy Associated Plasma Protein A (PAPP-A).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pregnancy Associated Plasma Protein A (PAPP-A) |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified |
| Size 1 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | Phosphate Buffered Saline, pH 7.4. Preservative: 0.09% Sodium Azide. |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. |
| Dry Ice | No |
| Alias | PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase |
| Background | Antibody anti-PAPPA |
| Status | RUO |
Descripción
PAPPA, also known as pregnancy-associated plasma protein-A, is a zinc-binding metalloproteinase that regulates the activity of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins (IGFBPs), specifically IGFBP-4 and IGFBP-5. This proteolytic activity increases the bioavailability of IGFs, which are crucial for cell growth, proliferation, and tissue repair. PAPPA is highly expressed during pregnancy, where it contributes to placental development and fetal growth, making it a key biomarker in prenatal screening for conditions like preeclampsia and Down syndrome. Outside of pregnancy, PAPPA is involved in regulating processes such as bone remodeling, wound healing, and inflammation. Elevated PAPPA expression has been observed in cardiovascular diseases and certain cancers, where it promotes IGF-mediated cell proliferation and tumor progression. Its role in modulating IGF signaling highlights its importance in both physiological and pathological conditions.
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