Pre-mRNA-Splicing Regulator WTAP (WTAP) Antibody

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383.5€ (100 µl)

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935106861
info@markelab.com
name
Pre-mRNA-Splicing Regulator WTAP (WTAP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx224138
tested applications
ELISA, IHC, FCM

Description

WTAP Antibody is a Mouse Monoclonal against WTAP.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Pre-mRNA-Splicing Regulator WTAP (WTAP)
Host
Mouse
Reactivity
Human
Recommended Dilution
ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Isotype
IgG1
Purification
Purified from ascites by Protein G chromatography.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, IHC, FCM
Buffer
PBS, containing 0.05% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q15007
Gene ID
9589
OMIM
605442
Background
Antibody anti-WTAP
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

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Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).

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