Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx171312
tested applications
WB
Description
Arachidonate-5-Lipoxygenase (ALOX5) Antibody is a Mouse Monoclonal antibody against Arachidonate-5-Lipoxygenase (ALOX5).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Immunogen: abx166486 - Recombinant 5-Lipoxygenase (5-LO) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b Kappa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ALOX5,LOG5 |
| Background | Antibody anti-ALOX5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ALOX5 is a key enzyme in the biosynthesis of leukotrienes, potent lipid mediators involved in inflammation, immune responses, and allergic reactions. ALOX5 catalyzes the oxidation of arachidonic acid to form 5-hydroperoxyeicosatetraenoic acid (5-HPETE), which is subsequently converted into leukotriene A4 (LTA4), the precursor for leukotrienes B4 (LTB4), C4 (LTC4), D4, and E4. These leukotrienes play significant roles in recruiting neutrophils, promoting vascular permeability, and inducing smooth muscle contraction. ALOX5 is highly expressed in immune cells such as neutrophils, eosinophils, and macrophages, where it mediates inflammatory responses to infection, injury, and allergens. Dysregulation of ALOX5 is associated with asthma, rheumatoid arthritis, atherosclerosis, and cancer, where leukotrienes amplify inflammation and promote tissue damage. In cancer, ALOX5 enhances tumor cell proliferation, survival, and angiogenesis through lipid signaling. As such, ALOX5 inhibitors, including zileuton, are used therapeutically for asthma and are being explored for anti-cancer treatments targeting lipid metabolism.
Related Products
Human Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Protein
Human Arachidonate-5-Lipoxygenase Protein is a recombinant Human protein expressed in E. coli.
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