Poliovirus Receptor (PVR) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Poliovirus Receptor (PVR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx101800
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Poliovirus Receptor (PVR).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Poliovirus Receptor (PVR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-5 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15151 |
| Alias | Poliovirus receptor,PVS,HVED,CD155,NECL5,TAGE4,Necl-5,Nectin-like protein 5 |
| Background | Antibody anti-PVR |
| Status | RUO |
Descripción
PVR, also known as CD155, is a cell adhesion molecule primarily involved in cell signaling, immune modulation, and viral entry. The gene encoding this protein is found on chromosome 19q13.31, and the protein was initially identified as the receptor for poliovirus, facilitating viral entry into cells. However, PVR is not limited to viral entry functions; it plays a significant role in immune cell interactions, migration, and tissue development. Structurally part of the immunoglobulin superfamily, PVR is widely expressed in various tissues, including epithelial cells, endothelial cells, and immune cells, and is upregulated in certain cancers, suggesting an adaptive role in tumor immune escape mechanisms. This protein is a primary ligand for several immune checkpoints such as DNAM-1 (CD226), TIGIT, and CD96, highlighting its importance in immune system modulation.
