Platelet Glycoprotein IX (GP9) Protein
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Description
GP9 is a recombinant protein.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Platelet Glycoprotein IX (GP9) |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P14770 |
| Alias | GPIX,CD42a,Platelet glycoprotein IX,GP-IX,Glycoprotein 9 |
| Background | Protein GP9 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Glycoprotein IX Platelet (GP9), also known as CD42a, is a critical component of the glycoprotein Ib-IX-V complex, which is essential for platelet adhesion and aggregation in the hemostatic process. GP9 is a small transmembrane glycoprotein predominantly expressed on the surface of platelets and megakaryocytes. It associates with glycoprotein Ib alpha (GPIbα), glycoprotein Ib beta (GPIbβ), and glycoprotein V (GPV) to form the functional receptor complex responsible for binding von Willebrand factor (vWF) under conditions of vascular injury and high shear stress. This interaction facilitates platelet adhesion to exposed subendothelial surfaces, initiating clot formation. Mutations in the GP9 gene can lead to Bernard-Soulier syndrome, a rare autosomal recessive disorder characterized by macrothrombocytopenia and defective platelet adhesion. Due to its involvement in thrombosis and hemostasis, GP9 has been studied as a potential therapeutic target in managing thrombotic disorders and cardiovascular diseases. Additionally, its expression levels serve as a marker for platelet maturation and megakaryocyte development.
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GP9 antibody
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
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Platelet Glycoprotein IX (GP9) Antibody
GP9 Antibody is a Rabbit Polyclonal antibody against GP9. This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
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Platelet Glycoprotein IX (GP9) Antibody
This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq].
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