Platelet Glycoprotein IX (GP9) Antibody
357.5€ (100 µg)
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Name
Platelet Glycoprotein IX (GP9) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx340134
Tested Applications
ELISA, IHC
Description
GP9 Antibody is a Rabbit Polyclonal against GP9.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Platelet Glycoprotein IX (GP9) Immunogen: Recombinant fragment corresponding to 18-133 AA of human GP9. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC030229 |
| Alias | GPIX,CD42a,Platelet glycoprotein IX,GP-IX,Glycoprotein 9 |
| Background | Antibody anti-GP9 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Glycoprotein IX Platelet (GP9), also known as CD42a, is a critical component of the glycoprotein Ib-IX-V complex, which is essential for platelet adhesion and aggregation in the hemostatic process. GP9 is a small transmembrane glycoprotein predominantly expressed on the surface of platelets and megakaryocytes. It associates with glycoprotein Ib alpha (GPIbα), glycoprotein Ib beta (GPIbβ), and glycoprotein V (GPV) to form the functional receptor complex responsible for binding von Willebrand factor (vWF) under conditions of vascular injury and high shear stress. This interaction facilitates platelet adhesion to exposed subendothelial surfaces, initiating clot formation. Mutations in the GP9 gene can lead to Bernard-Soulier syndrome, a rare autosomal recessive disorder characterized by macrothrombocytopenia and defective platelet adhesion. Due to its involvement in thrombosis and hemostasis, GP9 has been studied as a potential therapeutic target in managing thrombotic disorders and cardiovascular diseases. Additionally, its expression levels serve as a marker for platelet maturation and megakaryocyte development.
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