Platelet Glycoprotein Ib Alpha Chain (GP1BA) Antibody (APC)
429€ (100 tests)
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935106861
info@markelab.com
name
Platelet Glycoprotein Ib Alpha Chain (GP1BA) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx140559
tested applications
FCM
Description
Platelet Glycoprotein Ib Alpha Chain (GP1BA) Antibody (APC) is a Mouse Monoclonal against Platelet Glycoprotein Ib Alpha Chain (GP1BA).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Platelet Glycoprotein Ib Alpha Chain (GP1BA) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG1 |
| Clone ID | O725 |
| Purification | The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P07359 |
| Gene ID | 2811 |
| Alias | BSS,GP1B,VWDP,CD42B,GPIbA,BDPLT1,BDPLT3,DBPLT3,GPIbalpha,CD42b-alpha,Platelet glycoprotein Ib alpha chain,GP-Ib alpha,GPIb-alpha, Glycoprotein Ibalpha,CD42b-alpha |
| Background | Antibody anti-GP1BA |
| Status | RUO |
Descripción
Glycoprotein Ib platelet subunit alpha (GP1BA) is a critical component of the glycoprotein Ib-IX-V complex (GPIb-IX-V) on the surface of platelets. This complex plays a central role in the process of hemostasis, specifically in the adhesion of platelets to the damaged endothelium at sites of vascular injury. Hemostasis is crucial for preventing blood loss and initiating the wound healing process, and the proper functioning of the GPIb-IX-V complex is vital for platelet tethering under high shear stress conditions, such as in arterioles. GP1BA is the alpha subunit of GPIb, which is responsible for mediating the interaction with von Willebrand factor (vWF), a plasma glycoprotein that anchors platelets to the site of injury. Through its interactions with vWF, GP1BA enables the binding of platelets to exposed subendothelial matrix components, initiating platelet activation and aggregation.
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