Platelet Derived Growth Factor Receptor Beta Phospho-Tyr1021 (PDGFRB pY1021) Antibody
221€ (50 µg)
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Name
Platelet Derived Growth Factor Receptor Beta Phospho-Tyr1021 (PDGFRB pY1021) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx326698
Tested Applications
ELISA, WB, IHC
Description
PDGFRB (pY1021) Antibody is a Rabbit Polyclonal against PDGFRB (pY1021).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Platelet Derived Growth Factor Receptor Beta Phospho-Tyr1021 (PDGFRB pY1021) Immunogen: Synthesized peptide derived from human PDGFR-β around the phosphorylation site of Y1021. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/5000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09619 |
| Gene ID | 5159 |
| Alias | IMF1,KOGS,IBGC4,JTK12,PDGFR,PENTT,CD140B,PDGFR1,PDGFR-1,CD140 antigen-like family member B,Platelet-derived growth factor receptor 1,Beta-type platelet-derived growth factor receptor,PDGF-R-beta,PDGFR-beta |
| Background | Antibody anti-PDGFRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Platelet derived growth factor receptor beta (PDGFRB) similarly functions as a receptor for PDGFs and is crucial for vascular development and the regulation of blood vessel maturation and stability PDGFRB is expressed in pericytes and vascular smooth muscle cells, where it modulates cell migration, proliferation, and differentiation its activation is pivotal in angiogenesis and vascular remodeling through downstream signaling pathways including STAT3 and Ras-MAPK aberrations in PDGFRB signaling are implicated in pathologies such as proliferative retinopathies, atherosclerosis, and certain myeloproliferative disorders including chronic eosinophilic leukemia targeted inhibitors have been developed to counteract PDGFRB-driven malignancies while new studies focus on its contribution to immune modulation and tissue regeneration.