Platelet-derived growth factor receptor beta (PDGFRB) Antibody
299€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Platelet-derived growth factor receptor beta (PDGFRB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402109
Tested Applications
ELISA, IHC
Description
Platelet-derived growth factor receptor beta (PDGFRB) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human PDGFRB.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Platelet-derived growth factor receptor beta (PDGFRB) Immunogen: A synthesized peptide derived from human PDGF Receptor beta |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09619 |
| Alias | IMF1,KOGS,IBGC4,JTK12,PDGFR,PENTT,CD140B,PDGFR1,PDGFR-1,CD140 antigen-like family member B,Platelet-derived growth factor receptor 1,Beta-type platelet-derived growth factor receptor,PDGF-R-beta,PDGFR-beta |
| Background | Antibody anti-PDGFRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Platelet derived growth factor receptor beta (PDGFRB) similarly functions as a receptor for PDGFs and is crucial for vascular development and the regulation of blood vessel maturation and stability PDGFRB is expressed in pericytes and vascular smooth muscle cells, where it modulates cell migration, proliferation, and differentiation its activation is pivotal in angiogenesis and vascular remodeling through downstream signaling pathways including STAT3 and Ras-MAPK aberrations in PDGFRB signaling are implicated in pathologies such as proliferative retinopathies, atherosclerosis, and certain myeloproliferative disorders including chronic eosinophilic leukemia targeted inhibitors have been developed to counteract PDGFRB-driven malignancies while new studies focus on its contribution to immune modulation and tissue regeneration.
Productos relacionados
Platelet Derived Growth Factor Receptor Beta (PDGFRB) Antibody
PDGFRB Antibody is a Rabbit Polyclonal antibody against PDGFRB. This gene encodes a cell surface tyrosine kinase recepto…
Ver producto
Platelet Derived Growth Factor Receptor Beta (PDGFRB) Antibody
Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFR beta or CD140B. It is a cell surf…
Ver producto
PDGFRb (Phospho-Tyr771) Antibody
Rabbit polyclonal antibody against PDGFRb protein. Immunogen region is Internal. Specificity is as follows for the react…
Ver producto