Platelet Derived Growth Factor Receptor Beta (PDGFRB) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Platelet Derived Growth Factor Receptor Beta (PDGFRB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx033594
Tested Applications
ELISA, WB, IHC, IF/ICC, FCM
Description
PDGFRB is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses the gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Platelet Derived Growth Factor Receptor Beta (PDGFRB) Immunogen: KLH-conjugated synthetic peptide between 40-72 amino acids from the N-terminal region of human PDGFRB. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 124 kDa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09619 |
| Alias | IMF1,KOGS,IBGC4,JTK12,PDGFR,PENTT,CD140B,PDGFR1,PDGFR-1,CD140 antigen-like family member B,Platelet-derived growth factor receptor 1,Beta-type platelet-derived growth factor receptor,PDGF-R-beta,PDGFR-beta |
| Background | Antibody anti-PDGFRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Platelet derived growth factor receptor beta (PDGFRB) similarly functions as a receptor for PDGFs and is crucial for vascular development and the regulation of blood vessel maturation and stability PDGFRB is expressed in pericytes and vascular smooth muscle cells, where it modulates cell migration, proliferation, and differentiation its activation is pivotal in angiogenesis and vascular remodeling through downstream signaling pathways including STAT3 and Ras-MAPK aberrations in PDGFRB signaling are implicated in pathologies such as proliferative retinopathies, atherosclerosis, and certain myeloproliferative disorders including chronic eosinophilic leukemia targeted inhibitors have been developed to counteract PDGFRB-driven malignancies while new studies focus on its contribution to immune modulation and tissue regeneration.
Productos relacionados
Platelet Derived Growth Factor Receptor Beta (PDGFRB) Antibody
PDGFRB Antibody is a Rabbit Polyclonal antibody against PDGFRB. This gene encodes a cell surface tyrosine kinase recepto…
Ver producto
Platelet Derived Growth Factor Receptor Beta (PDGFRB) Antibody
Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFR beta or CD140B. It is a cell surf…
Ver producto
PDGFRb (Phospho-Tyr771) Antibody
Rabbit polyclonal antibody against PDGFRb protein. Immunogen region is Internal. Specificity is as follows for the react…
Ver producto