Platelet And Endothelial Cell Adhesion Molecule 1 (PECAM1) Antibody
416€ (200 µl)
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935106861
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name
Platelet And Endothelial Cell Adhesion Molecule 1 (PECAM1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433504
tested applications
P-ELISA, WB
Description
Platelet And Endothelial Cell Adhesion Molecule 1 (PECAM1) Antibody is a Goat Polyclonal Antibody against Platelet And Endothelial Cell Adhesion Molecule 1 (PECAM1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Platelet And Endothelial Cell Adhesion Molecule 1 (PECAM1) |
| Host | Goat |
| Reactivity | Mouse, Rat |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 18613 |
| NCBI Accession | NP_032842.2, NP_001027550.1 |
| Alias | CD31,PECA1,PECAM-1,endoCAM,CD31/EndoCAM,Platelet endothelial cell adhesion molecule,GPIIA' |
| Background | Antibody anti-PECAM1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
PECAM1 (Platelet and Endothelial Cell Adhesion Molecule 1), also known as CD31, is an integral member of the immunoglobulin (Ig) superfamily and functions primarily as a cell adhesion molecule. It plays critical roles in various physiological and pathological processes, including leukocyte transmigration, angiogenesis, vascular integrity, and immune response regulation. PECAM-1 is highly expressed on the surface of endothelial cells lining blood vessels, platelets, monocytes, neutrophils, and some subsets of T cells. Its pivotal role in mediating cell-cell interactions makes it central to maintaining vascular homeostasis and coordinating immune responses. PECAM-1 is widely recognized for its involvement in processes like leukocyte extravasation, where it facilitates the migration of immune cells across the endothelium during inflammation. Additionally, it serves as an essential player in maintaining the structural integrity of the vascular endothelium and modulating signaling pathways linked to cell survival and inflammation. Given its broad expression and functional diversity, PECAM-1 has been a focal point of research in vascular biology, inflammation, and cardiovascular diseases.
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