Platelet And Endothelial Cell Adhesion Molecule 1 (CD31) Antibody
572€ (2 ml)
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Name
Platelet And Endothelial Cell Adhesion Molecule 1 (CD31) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx413322
Tested Applications
IHC, FCM
Description
Platelet And Endothelial Cell Adhesion Molecule 1 (CD31) Antibody is a Mouse Monoclonal antibody against Platelet And Endothelial Cell Adhesion Molecule 1 (CD31).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Platelet And Endothelial Cell Adhesion Molecule 1 (CD31) |
| Host | Mouse |
| Reactivity | Pig |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgM |
| Purification | Unpurified supernatant |
| Size 1 | 2 ml |
| Form | Liquid |
| Tested Applications | IHC, FCM |
| Buffer | Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q95242 |
| Alias | CD31,PECA1,PECAM-1,endoCAM,CD31/EndoCAM,Platelet endothelial cell adhesion molecule,GPIIA' |
| Background | Antibody anti-PECAM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PECAM1 (Platelet and Endothelial Cell Adhesion Molecule 1), also known as CD31, is an integral member of the immunoglobulin (Ig) superfamily and functions primarily as a cell adhesion molecule. It plays critical roles in various physiological and pathological processes, including leukocyte transmigration, angiogenesis, vascular integrity, and immune response regulation. PECAM-1 is highly expressed on the surface of endothelial cells lining blood vessels, platelets, monocytes, neutrophils, and some subsets of T cells. Its pivotal role in mediating cell-cell interactions makes it central to maintaining vascular homeostasis and coordinating immune responses. PECAM-1 is widely recognized for its involvement in processes like leukocyte extravasation, where it facilitates the migration of immune cells across the endothelium during inflammation. Additionally, it serves as an essential player in maintaining the structural integrity of the vascular endothelium and modulating signaling pathways linked to cell survival and inflammation. Given its broad expression and functional diversity, PECAM-1 has been a focal point of research in vascular biology, inflammation, and cardiovascular diseases.
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