Pig Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Protein

Este producto es parte de FLT1 - fms related receptor tyrosine kinase 1
Pig Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Protein
429€ (50 µg)

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Name
Pig Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx069649
Tested Applications
WB, SDS-PAGE

Description

Pig Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) is a recombinant Pig protein expressed in E. coli. The predicted isoelectric point for this protein is 8.4.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Lys19-Leu146
Tag: N-terminal His tag and GST tag
Origin
Pig
Conjugation
Unconjugated
Observed MW
Calculated MW: 44.8 kDa  Observed MW: 45 kDa (determined by SDS-PAGE)
Expression
Recombinant
Purity
> 98%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
ACH73486.1
Alias
FLT,FLT-1,VEGFR1,VEGFR-1,Vascular permeability factor receptor,Fms-like tyrosine kinase 1,Vascular endothelial growth factor receptor 1
Background
Protein FLT1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

Fms related receptor tyrosine kinase 1 (FLT1) FLT1, also known as vascular endothelial growth factor receptor 1 (VEGFR1), is a transmembrane tyrosine kinase receptor that binds vascular endothelial growth factors (VEGFs) and placental growth factor (PlGF). FLT1 plays a crucial role in angiogenesis, vascular development, and inflammation by regulating endothelial cell proliferation, migration, and survival. Structurally, FLT1 consists of an extracellular ligand-binding domain with seven immunoglobulin-like loops, a transmembrane domain, and an intracellular kinase domain. FLT1 can function as a signaling receptor or a decoy receptor, depending on its membrane-bound or soluble isoforms, modulating VEGF availability and signaling intensity. It is highly expressed in endothelial cells and trophoblasts, contributing to processes such as placental development and vascular remodeling. Dysregulation of FLT1 is implicated in pathological conditions, including cancer, where it promotes tumor angiogenesis, and preeclampsia, where excessive FLT1 activity leads to impaired placental and vascular function. Its dual role as a regulator of VEGF signaling and a therapeutic target underscores its importance in both physiological and pathological angiogenesis.

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