Pig Lactate Dehydrogenase A (LDHA) Protein

Este producto es parte de LDHA - Lactate Dehydrogenase A
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416€ (50 µg)

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935106861
info@markelab.com
name
Pig Lactate Dehydrogenase A (LDHA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167519
tested applications
WB, SDS-PAGE

Description

Lactate Dehydrogenase A Protein is a recombinant Pig protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Lactate Dehydrogenase A (LDHA)
Host
E. coli
Origin
Pig
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 66.6 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Met1-Phe332

Tag: N-terminal His tag and GST tag
Expression
Recombinant
Purity
> 90%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
LDHM, GSD11,PIG1,HEL-S-133P,lactate Dehydrogenase A,prolifeRation-inducing gene 19
Background
Protein LDHA
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Lactate Dehydrogenase A (LDHA) is an enzyme that catalyzes the conversion of pyruvate to lactate in the final step of anaerobic glycolysis. LDHA plays a critical role in cellular energy metabolism, especially under hypoxic conditions, where it helps regenerate NAD+ for glycolysis. It is highly expressed in tissues with high glycolytic activity, such as skeletal muscle. In cancer, LDHA is upregulated as part of the Warburg effect, where tumor cells preferentially use glycolysis for energy production, even in the presence of oxygen. Elevated LDHA expression is associated with tumor growth, metastasis, and resistance to therapy, making it a target for anticancer therapies. Beyond cancer, LDHA is implicated in metabolic disorders and muscular diseases, highlighting its importance in both normal physiology and pathological conditions.

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