Pig Interleukin 2 Receptor Gamma (IL2RG) Protein
494€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Pig Interleukin 2 Receptor Gamma (IL2RG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx655891
tested applications
WB, SDS-PAGE
Description
Pig Interleukin 2 Receptor Gamma Protein is a recombinant Pig protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 2 Receptor Gamma (IL2RG) |
| Host | E. coli |
| Origin | Pig |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 30.8 kDa Observed MW (SDS-PAGE): 31 kDa Concentration: Prior to lyophilization: 50 µg/ml Sequence Fragment: Leu23-Pro254 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Cytokine receptor common subunit gamma,P64,CIDX,IMD4,CD132,SCIDX,IL-2RG,SCIDX1,IL-2 receptor subunit gamma,IL-2R subunit gamma |
| Background | Protein IL2RG |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The Interleukin 2 Receptor Subunit Gamma (IL2RG), also known as the common gamma chain or γc, is a crucial component of several cytokine receptor complexes, specifically those for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Each of these cytokines plays a vital role in immune cell development, activation, and homeostasis. Because IL2RG is part of multiple cytokine receptor systems, it is often referred to as a "common" subunit, essential for the signaling functionality of these cytokines. The expression of IL2RG is indispensable for immune competence, influencing processes in adaptive immunity and innate immune responses. In its absence, severe immunodeficiency conditions, such as X-linked severe combined immunodeficiency (X-SCID), can occur, indicating its role in T cell, B cell, and natural killer (NK) cell development. IL2RG does not directly bind to cytokines but facilitates signal transduction by forming a complex with cytokine-specific receptor subunits and initiating intracellular signaling cascades. The signaling through IL2RG activates critical pathways, including JAK/STAT, MAPK, and PI3K/AKT, which are integral to immune cell differentiation, proliferation, and survival. Due to the centrality of IL2RG in immune system function, mutations in this gene have severe implications for immune cell functionality and host defense.
Related Products
Human IL2RG(Cytokine receptor common subunit gamma) ELISA Kit
Ver Producto
Interleukin 2 Receptor, Gamma (IL2RG) Antibody
IL2RG Antibody is a Rabbit Polyclonal antibody against IL2RG. The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010].
Ver Producto