Pig Interleukin 2 Receptor Alpha (IL2RA) Protein

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935106861
info@markelab.com
Precio
455€ (50 µg)
Protein IL2RA
proveedor
Abbexareference
abx168471Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Pig Interleukin 2 Receptor Alpha Protein is a recombinant Pig protein expressed in E. coli.
Background
Interleukin 2 receptor subunit alpha (IL2RA), also known as CD25, is a crucial component of the high-affinity interleukin-2 (IL-2) receptor complex, which is essential for regulating immune responses, particularly T-cell proliferation and survival. The IL-2 receptor plays a pivotal role in both adaptive immunity and immune tolerance, with IL2RA being one of the three subunits that form the IL-2 receptor complex. The IL-2 receptor system is critically involved in the regulation of T-cell homeostasis, immune activation, and the suppression of autoimmunity. IL2RA is primarily expressed on activated T cells, particularly regulatory T cells (Tregs), which are crucial for maintaining immune tolerance. It is also found on other immune cells, including activated B cells, dendritic cells, and natural killer (NK) cells under certain conditions. Importantly, IL2RA expression is tightly regulated, being upregulated upon T-cell activation and playing a central role in fine-tuning immune responses.
Características del producto
category
Proteins and Peptides
origin
Pig
host
E. coli
immunogen target
Interleukin 2 Receptor Alpha (IL2RA)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 29.1 kDa Observed MW (SDS-PAGE): 33 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 250 µg/ml Sequence Fragment: Gly22-Gln245 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL2RA
dry ice
No
availability
Shipped within 5-7 working days.
alias
p55,CD25,IL2R,IMD41,TCGFR,IDDM10,Interleukin-2 receptor subunit alpha,IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA,TAC antigen
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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