Phospholipid-transporting ATPase ABCA3 (ABCA3) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Phospholipid-transporting ATPase ABCA3 (ABCA3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx340981
tested applications
ELISA, WB, IF/ICC
Description
Phospholipid-transporting ATPase ABCA3 (ABCA3) Antibody is a Rabbit Polyclonal antibody for the detection of Human ABCA3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Phospholipid-transporting ATPase ABCA3 (ABCA3) Immunogen: Synthetic peptide of human ABCA3 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000 - 1/5000, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3, 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99758 |
| Gene ID | 21 |
| OMIM | 601615 |
| Alias | ABC-C,ABC3,LBM180,SMDP3 |
| Background | Antibody anti-ABCA3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ABCA3 is a critical protein in pulmonary surfactant production, predominantly expressed in alveolar type II epithelial cells in the lungs. It plays an essential role in transporting phospholipids and cholesterol into lamellar bodies, which are specialized organelles where surfactant is stored before secretion. ABCA3 utilizes ATP hydrolysis to facilitate lipid transport, ensuring the proper composition and function of surfactant, which reduces surface tension in the alveoli and prevents lung collapse. Mutations in the ABCA3 gene are associated with surfactant metabolism disorders, including neonatal respiratory distress syndrome and interstitial lung disease. These conditions are characterized by impaired surfactant production, leading to respiratory failure. ABCA3’s function in lipid transport and its critical role in pulmonary physiology underscore its importance in respiratory health.
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