Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) Antibody
169€ (20 µg)
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935106861
info@markelab.com
name
Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx333732
tested applications
ELISA, IF/ICC
Description
PIK3AP1 Antibody is a Rabbit Polyclonal against PIK3AP1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ZUJ8 |
| Gene ID | 118788 |
| Alias | B Cell Adaptor Protein,BCAP |
| Background | Antibody anti-PIK3AP1 |
| Status | RUO |
Descripción
Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1), also known as BCAP (B-cell adaptor for PI3K), is a key adaptor protein involved in linking receptor-mediated signaling to the activation of phosphoinositide 3-kinase (PI3K) pathways, which are critical for cell survival, proliferation, and immune responses. PIK3AP1 is predominantly expressed in immune cells such as B lymphocytes, where it plays an essential role in B-cell receptor (BCR) signaling, promoting downstream PI3K-mediated activation of Akt and mTOR pathways. This activation facilitates cellular processes like growth, metabolism, and differentiation. PIK3AP1 also functions in Toll-like receptor (TLR) signaling in innate immune cells, such as macrophages, to regulate inflammatory responses and cytokine production. Dysregulation of PIK3AP1 has been implicated in immune disorders, including autoimmunity and immunodeficiency, as well as in cancer, where aberrant PI3K signaling contributes to tumor growth and resistance to apoptosis. Its interactions with signaling molecules, such as SH2 domain-containing proteins, ensure specificity and dynamic regulation of immune and cellular responses. Emerging studies suggest that targeting PIK3AP1 or its associated pathways holds therapeutic potential for modulating immune responses or treating malignancies with hyperactive PI3K signaling.
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