Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) Antibody
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Description
Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) Antibody is a Rabbit polyclonal antibody for the detection of Human Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92835 |
| Gene ID | 3635 |
| NCBI Accession | NP_001017915.1 |
| Background | Antibody anti-INPP5D |
| Status | RUO |
Descripción
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Human INPP5D(Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1) ELISA Kit
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anti- INPP5D antibody
Phosphatidylinositol(PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate(PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K(phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor(FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
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