Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha (PIK3R1) Antibody

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Description
Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha (PIK3R1) Antibody is a Mouse Monoclonal antibody against PI-3 KINASE p85 SUBUNIT ALPHA.
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Product specifications
Category | Primary Antibodies |
Immunogen Target | Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha (PIK3R1) |
Host | Mouse |
Reactivity | Cow |
Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | IgG1 |
Purification | Purified |
Size 1 | 200 µg |
Form | Liquid |
Tested Applications | WB, IHC, IP |
Buffer | PBS. Contains sodium azide. |
Availability | Shipped within 3-7 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P23727, P26450, P27986, Q63787 |
Background | Antibody anti-PIK3R1 |
Status | RUO |
Note | Concentration: 1.0 mg/ml - |
Descripción
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PIK3R1 antibody
Phosphatidylinositol 3-kinase (PI3K) plays an important role in the metabolic actions of insulin and is required for adipogenesis. The PI3K pathway has also been identified as an important player in cancer development and progression. The Class IA PI3K heterodimer, which is composed of a P110 catalytic subunit and a P85 regulatory subunit, is activated upon association of the P85 subunit with upstream adaptor proteins or receptor tyrosine kinases. Mutations in PIK3R1 are implicated in cases of breast cancer and associated to SHORT syndrome.
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PIK3R1 antibody
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.
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PIK3R1 antibody
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.
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