PHD Finger Protein 7 (PHF7) Antibody (Biotin)
169€ (20 µg)
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name
PHD Finger Protein 7 (PHF7) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx344104
tested applications
ELISA
Description
PHD Finger Protein 7 (PHF7) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human PHF7.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 7 (PHF7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BWX1 |
| Alias | HSPC045, HSPC226, NYD-SP6,Testis development protein NYD-SP6 |
| Background | Antibody anti-PHF7 |
| Status | RUO |
Descripción
PHF7 is a histone-binding protein containing a PHD finger domain that recognizes methylated histones, particularly H3K4me3, to regulate transcriptional activation. PHF7 plays a role in spermatogenesis and male fertility by coordinating chromatin remodeling and gene expression during germ cell development. It interacts with transcriptional regulators and chromatin modifiers to activate genes essential for germ cell differentiation and meiosis. PHF7 is specifically expressed in testicular tissues, where it facilitates proper gene expression programs for spermatocyte maturation. Dysregulation or mutations in PHF7 are associated with male infertility due to disrupted spermatogenesis and impaired germ cell differentiation. Knockdown studies reveal defective chromatin remodeling, reduced germ cell proliferation, and meiotic arrest, emphasizing its role in transcriptional activation, germline development, and reproductive health.
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