Peroxisome Proliferator Activated Receptor Alpha (PPARa) Antibody Pair
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Description
Peroxisome Proliferator Activated Receptor Alpha (PPARa) Antibody Pair for use in Sandwich ELISA assay development.
Documents del producto
Product specifications
| Category | Antibody Pairs |
| Immunogen Target | Peroxisome Proliferator Activated Receptor Alpha (PPARa) |
| Reactivity | Human |
| Assay Data | Detection Antibody Biotinilated |
| Assay Type | Sandwich |
| Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 5 × 96 tests |
| Size 2 | 10 × 96 tests |
| Form | Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
| Tested Applications | ELISA |
| Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | PPAR,NR1C1,Hppar,PPARalpha,PPAR-alpha,Nuclear receptor subfamily 1 group C member 1 |
| Background | Antibody Pair for PPARA |
| Status | RUO |
| Note | This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only. |
Descripción
Peroxisome proliferator activated receptor alpha (PPARA) is a nuclear hormone receptor that plays a critical role in the regulation of lipid metabolism, inflammation, and energy homeostasis PPARA is primarily expressed in tissues involved in fatty acid metabolism, such as the liver, heart, and skeletal muscle, where it regulates the transcription of genes involved in the breakdown of fatty acids and lipids The receptor functions by binding to specific ligands, such as fatty acids and fibrates, which activate PPARA and induce the expression of genes involved in lipid catabolism, mitochondrial biogenesis, and oxidative stress response PPARA is also involved in regulating glucose metabolism and insulin sensitivity, making it a key player in metabolic diseases like diabetes and obesity Dysregulation of PPARA has been linked to various disorders, including cardiovascular diseases, metabolic syndrome, and fatty liver disease PPARA's role in regulating inflammation further highlights its therapeutic potential in conditions characterized by chronic inflammation, including atherosclerosis and neurodegenerative diseases
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PPARA antibody
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine(16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
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