Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A (FKBP1A) Antibody
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Description
Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A (FKBP1A) Antibody is a Rabbit polyclonal antibody for the detection of Human Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A (FKBP1A).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A (FKBP1A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P62942 |
| Gene ID | 2280 |
| NCBI Accession | NP_000792.1 |
| Background | Antibody anti-FKBP1A |
| Status | RUO |
Descripción
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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
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