PDPK1 (pS396) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
PDPK1 (pS396) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx031991
Tested Applications
ELISA, DB
Description
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3, 4, 5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: PDPK1 (pS396) Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S396 of human PDPK1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 63.2 kDa |
| Purification | Purified in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, DB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15530 |
| Background | Antibody anti-PDPK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Productos relacionados
PDPK1 (pS241) Antibody
PDPK1 (pS241) Antibody is a Rabbit Polyclonal antibody against PDPK1 (pS241).…
Ver producto
Phosphoinositide Dependent Protein Kinase 1 (PDPK1) Antibody
PDPK1 Antibody is a Rabbit Polyclonal antibody against PDPK1.…
Ver producto
Phosphoinositide Dependent Protein Kinase 1 (PDPK1) Antibody
PDPK1 Antibody is a Mouse Monoclonal against PDPK1.…
Ver producto