Paired box protein Pax-8 (PAX8) Antibody (FITC)
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Paired box protein Pax-8 (PAX8) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx344050
Description
Paired box protein Pax-8 (PAX8) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human PAX8.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Paired box protein Pax-8 (PAX8) Immunogen: Recombinant Human Paired box protein Pax-8 protein (237-450 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q06710 |
| Alias | PAX-8 |
| Background | Antibody anti-PAX8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PAX8 is a transcription factor required for the development of the thyroid gland, kidneys, and parts of the reproductive system. During embryogenesis, PAX8 regulates genes necessary for thyroid follicular cell differentiation and hormone synthesis, making it essential for thyroid gland formation and function. Mutations in PAX8 are associated with congenital hypothyroidism, thyroid dysgenesis, and impaired thyroglobulin production. PAX8 also plays a role in nephrogenesis, contributing to kidney development and epithelial cell differentiation. In cancers, PAX8 is frequently overexpressed in thyroid, ovarian, and renal cell carcinomas, where it serves as a diagnostic marker and regulator of oncogenic pathways. Knockout models show thyroid gland agenesis, defective renal development, and reproductive abnormalities, highlighting PAX8's role in tissue-specific gene regulation, organogenesis, and endocrine function.
Productos relacionados
Paired Box Protein Pax-8 (PAX8) Antibody
PAX8 Antibody is a Rabbit Polyclonal antibody against PAX8. PAX8 is a member of the paired box (PAX) family of transcrip…
Ver producto
Paired Box 8 (PAX8) Antibody
This gene encodes a member of the paired box (PAX) family of transcription factors.Members of this gene family typically…
Ver producto
Paired Box Protein Pax-8 (PAX8) Antibody
PAX8 is a member of the paired box (PAX) family of transcription factors. Members of this family contain a paired box do…
Ver producto