Paired Box Protein Pax-8 (PAX8) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Paired Box Protein Pax-8 (PAX8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx236136
tested applications
ELISA, WB, IHC, IP
Description
Pan-PAX Antibody is a Rabbit Polyclonal against Pan-PAX.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box Protein Pax-8 (PAX8) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/500, IP: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q06710 |
| Gene ID | 7849 |
| Alias | PAX-8 |
| Background | Antibody anti-PAX8 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
PAX8 is a transcription factor required for the development of the thyroid gland, kidneys, and parts of the reproductive system. During embryogenesis, PAX8 regulates genes necessary for thyroid follicular cell differentiation and hormone synthesis, making it essential for thyroid gland formation and function. Mutations in PAX8 are associated with congenital hypothyroidism, thyroid dysgenesis, and impaired thyroglobulin production. PAX8 also plays a role in nephrogenesis, contributing to kidney development and epithelial cell differentiation. In cancers, PAX8 is frequently overexpressed in thyroid, ovarian, and renal cell carcinomas, where it serves as a diagnostic marker and regulator of oncogenic pathways. Knockout models show thyroid gland agenesis, defective renal development, and reproductive abnormalities, highlighting PAX8's role in tissue-specific gene regulation, organogenesis, and endocrine function.
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