Paired Box Protein Pax-5 (PAX5) Cell ELISA Kit
513.5€ (96 tests)
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935106861
info@markelab.com
name
Paired Box Protein Pax-5 (PAX5) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595463
tested applications
ELISA
Description
Pax-5 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Paired Box Protein Pax-5 (PAX5) |
| Reactivity | Human, Mouse |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q02548 |
| Gene ID | 5079 |
| OMIM | 167414 |
| Alias | ALL3,BSAP,PAX-5,B-cell-specific transcription factor |
| Background | Elisa kits for PAX5 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PAX5 is a critical transcription factor that governs B-cell lineage commitment, differentiation, and survival during hematopoiesis. PAX5 activates B-cell-specific gene expression while repressing alternative lineage programs to ensure B-cell identity. It is expressed in pro-B cells and remains active throughout B-cell maturation, where it regulates immunoglobulin gene rearrangement, signaling, and antigen response. Dysregulation or mutations in PAX5 are commonly observed in B-cell acute lymphoblastic leukemia (B-ALL), where its loss contributes to impaired B-cell differentiation and leukemogenesis. PAX5 also participates in neural and midbrain development during embryogenesis. Knockout models show arrested B-cell development at the pro-B stage and defects in midbrain formation, highlighting its role in both hematopoiesis and neurodevelopment. In cancer, altered PAX5 expression disrupts immune regulation, contributes to lymphomagenesis, and serves as a biomarker for diagnosing B-cell malignancies.
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