Paired Box Protein Pax-5 (PAX5) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Paired Box Protein Pax-5 (PAX5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430091
tested applications
P-ELISA, WB, IF/ICC
Description
PAX5 Antibody is a Goat Polyclonal antibody against PAX5.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box Protein Pax-5 (PAX5) |
| Host | Goat |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | P-ELISA: 1/64000, WB: 0.1-0.5 µg/ml, IF/ICC: 10 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IF/ICC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 5079, 18507 |
| NCBI Accession | NP_057953.1 |
| Alias | ALL3,BSAP,PAX-5,B-cell-specific transcription factor |
| Background | Antibody anti-PAX5 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
PAX5 is a critical transcription factor that governs B-cell lineage commitment, differentiation, and survival during hematopoiesis. PAX5 activates B-cell-specific gene expression while repressing alternative lineage programs to ensure B-cell identity. It is expressed in pro-B cells and remains active throughout B-cell maturation, where it regulates immunoglobulin gene rearrangement, signaling, and antigen response. Dysregulation or mutations in PAX5 are commonly observed in B-cell acute lymphoblastic leukemia (B-ALL), where its loss contributes to impaired B-cell differentiation and leukemogenesis. PAX5 also participates in neural and midbrain development during embryogenesis. Knockout models show arrested B-cell development at the pro-B stage and defects in midbrain formation, highlighting its role in both hematopoiesis and neurodevelopment. In cancer, altered PAX5 expression disrupts immune regulation, contributes to lymphomagenesis, and serves as a biomarker for diagnosing B-cell malignancies.
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