Paired Box Protein Pax-1 (PAX1) Antibody
221€ (50 µg)
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Name
Paired Box Protein Pax-1 (PAX1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx324755
Tested Applications
ELISA, WB, IHC
Description
PAX1 Antibody is a Rabbit Polyclonal against PAX1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Paired Box Protein Pax-1 (PAX1) Immunogen: Synthesized peptide derived from the Internal region of human Pax-1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15863 |
| Gene ID | 5075 |
| Alias | OFC2,HUP48,OTFCS2 |
| Background | Antibody anti-PAX1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PAX1 is a transcription factor that belongs to the paired box (PAX) family, which regulates embryonic development and tissue differentiation. PAX1 is essential for skeletal development, particularly in vertebral column formation, where it controls the proliferation and differentiation of mesodermal cells into sclerotome-derived structures. It binds DNA through its paired domain and activates the transcription of genes involved in chondrogenesis and axial skeletal patterning. Mutations or deletions in PAX1 are associated with congenital vertebral anomalies and conditions such as oto-spondylo-megaepiphyseal dysplasia (OSMED), characterized by skeletal abnormalities and hearing loss. PAX1 is also expressed in thymic epithelial cells, where it may contribute to thymus development and T cell maturation. Loss-of-function studies in mice reveal vertebral malformations, impaired cartilage differentiation, and developmental defects, underscoring PAX1's role in skeletal morphogenesis, chondrogenesis, and embryonic tissue development.
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