Paired Box 8 (PAX8) Antibody

Este producto es parte de PAX - Paired box protein Pax
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416€ (200 µl)

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935106861
info@markelab.com
name
Paired Box 8 (PAX8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433098
tested applications
P-ELISA, WB

Description

PAX8 Antibody is a Goat Polyclonal antibody against PAX8.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetPaired Box 8 (PAX8)
HostGoat
ReactivityHuman
Recommended DilutionP-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1200 µl
FormLiquid
Tested ApplicationsP-ELISA, WB
BufferTris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
Gene ID7849
NCBI AccessionNP_003457.1, NP_039245.1, NP_039246.1, NP_039247.1, NP_054698.1
AliasPAX-8
BackgroundAntibody anti-PAX8
StatusRUO
NoteConcentration: 0.5 mg/ml -

Descripción

PAX8 is a transcription factor required for the development of the thyroid gland, kidneys, and parts of the reproductive system. During embryogenesis, PAX8 regulates genes necessary for thyroid follicular cell differentiation and hormone synthesis, making it essential for thyroid gland formation and function. Mutations in PAX8 are associated with congenital hypothyroidism, thyroid dysgenesis, and impaired thyroglobulin production. PAX8 also plays a role in nephrogenesis, contributing to kidney development and epithelial cell differentiation. In cancers, PAX8 is frequently overexpressed in thyroid, ovarian, and renal cell carcinomas, where it serves as a diagnostic marker and regulator of oncogenic pathways. Knockout models show thyroid gland agenesis, defective renal development, and reproductive abnormalities, highlighting PAX8's role in tissue-specific gene regulation, organogenesis, and endocrine function.
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