Paired Box Protein Pax-7 (PAX7) Antibody
357.5€ (100 µg)
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Name
Paired Box Protein Pax-7 (PAX7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx340001
Tested Applications
ELISA, WB
Description
PAX7 Antibody is a Rabbit Polyclonal against PAX7.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Paired Box Protein Pax-7 (PAX7) Immunogen: Recombinant fragment corresponding to 84-277 AA of human PAX7. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 56 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23759 |
| Gene ID | 5081 |
| NCBI Accession | BC121165 |
| OMIM | 167410 |
| Alias | CMYP19,HUP1,MYOSCO,PAX7B,RMS2 |
| Background | Antibody anti-PAX7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PAX7 is a transcription factor essential for the specification and maintenance of skeletal muscle satellite cells, which are responsible for muscle growth, repair, and regeneration. It is expressed during embryonic development and in adult muscle progenitor cells, where it regulates myogenesis by activating target genes involved in muscle lineage commitment. PAX7 cooperates with MyoD to ensure muscle cell proliferation while inhibiting premature differentiation. In cancer, PAX7 is implicated in alveolar rhabdomyosarcoma through chromosomal translocations that generate oncogenic fusion proteins, such as PAX7-FOXO1, promoting tumorigenesis and cell survival. Knockout models of PAX7 exhibit impaired satellite cell maintenance, muscle regeneration failure, and reduced muscle mass. Its essential role in skeletal muscle homeostasis and regenerative biology positions PAX7 as a key player in muscle-related disorders, stem cell biology, and tumorigenesis.
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