Paired Box 1 (PAX1) Antibody
416€ (200 µl)
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935106861
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name
Paired Box 1 (PAX1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431488
tested applications
P-ELISA, WB
Description
PAX1 Antibody is a Goat Polyclonal antibody against PAX1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box 1 (PAX1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 5075, 18503, 311505 |
| NCBI Accession | NP_006183.2 |
| Alias | OFC2,HUP48,OTFCS2 |
| Background | Antibody anti-PAX1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
PAX1 is a transcription factor that belongs to the paired box (PAX) family, which regulates embryonic development and tissue differentiation. PAX1 is essential for skeletal development, particularly in vertebral column formation, where it controls the proliferation and differentiation of mesodermal cells into sclerotome-derived structures. It binds DNA through its paired domain and activates the transcription of genes involved in chondrogenesis and axial skeletal patterning. Mutations or deletions in PAX1 are associated with congenital vertebral anomalies and conditions such as oto-spondylo-megaepiphyseal dysplasia (OSMED), characterized by skeletal abnormalities and hearing loss. PAX1 is also expressed in thymic epithelial cells, where it may contribute to thymus development and T cell maturation. Loss-of-function studies in mice reveal vertebral malformations, impaired cartilage differentiation, and developmental defects, underscoring PAX1's role in skeletal morphogenesis, chondrogenesis, and embryonic tissue development.
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