P-Selectin (SELP) Antibody (PE)
234€ (25 tests)
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935106861
info@markelab.com
name
P-Selectin (SELP) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx414167
tested applications
FCM
Description
CD62 Antigen-Like Family Member P (CD62P) Antibody (PE) is a Mouse Monoclonal antibody against CD62 Antigen-Like Family Member P (CD62P).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | P-Selectin (SELP) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 25 tests |
| Size 2 | 100 tests |
| Form | Lyophilized |
| Tested Applications | FCM |
| Buffer | PBS, 1% BSA. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Store at -20 °C or -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16109, P42201, P98106 |
| Alias | CD62,GRMP,PSEL,CD62P,GMP140,LECAM3,PADGEM,P-selectin,CD62 antigen-like family member P,Granule membrane protein 140,Leukocyte-endothelial cell adhesion molecule 3,Platelet activation dependent granule-external membrane protein |
| Background | Antibody anti-SELP |
| Status | RUO |
Descripción
Selectin P (SELP), also known as P-selectin, is a cell adhesion molecule that plays a key role in inflammation, hemostasis, and immune response by mediating the interaction between platelets, endothelial cells, and leukocytes. P-selectin is primarily stored in the alpha granules of platelets and the Weibel-Palade bodies of endothelial cells and is rapidly mobilized to the cell surface upon cellular activation. The SELP gene, which encodes P-selectin, is located on chromosome 1q24.2. It belongs to the selectin family, which includes L-selectin (SELL), E-selectin (SELE), and P-selectin (SELP), all of which are involved in the early stages of leukocyte trafficking during inflammatory responses. P-selectin functions in the rolling and adhesion of leukocytes to the endothelium, a critical step in immune surveillance and the recruitment of immune cells to sites of tissue damage or infection. In the context of inflammation, it facilitates the rapid interaction between leukocytes and the vascular wall, allowing for their migration into the affected tissue. Its ligands include P-selectin glycoprotein ligand-1 (PSGL-1), which is found on the surface of leukocytes. P-selectin's involvement in thrombus formation is also crucial, as it mediates interactions between activated platelets and the endothelium, contributing to thrombosis.
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