P-Selectin (SELP) Antibody

Este producto es parte de SELP - selectin P
Product Graph
494€ (200 µg)

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935106861
info@markelab.com
name
P-Selectin (SELP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx415532
tested applications
ELISA, WB, IHC, IF/ICC

Description

CD62 Antigen-Like Family Member P (CD62P) Antibody is a Mouse Monoclonal antibody against CD62 Antigen-Like Family Member P (CD62P).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
P-Selectin (SELP)
Host
Mouse
Reactivity
Human
Recommended Dilution
Validated in IHC-F and IHC-P. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purification
Purified
Size 1
200 µg
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
PBS. Contains sodium azide.
Availability
Shipped within 3-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P16109
Alias
CD62,GRMP,PSEL,CD62P,GMP140,LECAM3,PADGEM,P-selectin,CD62 antigen-like family member P,Granule membrane protein 140,Leukocyte-endothelial cell adhesion molecule 3,Platelet activation dependent granule-external membrane protein
Background
Antibody anti-SELP
Status
RUO
Note
Concentration: 1.0 mg/ml - 

Descripción

Selectin P (SELP), also known as P-selectin, is a cell adhesion molecule that plays a key role in inflammation, hemostasis, and immune response by mediating the interaction between platelets, endothelial cells, and leukocytes. P-selectin is primarily stored in the alpha granules of platelets and the Weibel-Palade bodies of endothelial cells and is rapidly mobilized to the cell surface upon cellular activation. The SELP gene, which encodes P-selectin, is located on chromosome 1q24.2. It belongs to the selectin family, which includes L-selectin (SELL), E-selectin (SELE), and P-selectin (SELP), all of which are involved in the early stages of leukocyte trafficking during inflammatory responses. P-selectin functions in the rolling and adhesion of leukocytes to the endothelium, a critical step in immune surveillance and the recruitment of immune cells to sites of tissue damage or infection. In the context of inflammation, it facilitates the rapid interaction between leukocytes and the vascular wall, allowing for their migration into the affected tissue. Its ligands include P-selectin glycoprotein ligand-1 (PSGL-1), which is found on the surface of leukocytes. P-selectin's involvement in thrombus formation is also crucial, as it mediates interactions between activated platelets and the endothelium, contributing to thrombosis.

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