NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody
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Description
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody is a Goat Polyclonal against NUMB Like, Endocytic Adaptor Protein (NUMBL).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | NUMB Like, Endocytic Adaptor Protein (NUMBL) |
| Host | Goat |
| Reactivity | Mouse |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Size 1 | 200 µl |
| Tested Applications | P-ELISA, WB, IHC |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 9253 |
| NCBI Accession | NP_004747.1 |
| Background | Antibody anti-NUMBL |
| Status | RUO |
Descripción
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Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
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