Nucleotide-Binding Oligomerization Domain-Containing Protein 1 (NOD1) Antibody
442€ (200 µl)
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935106861
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name
Nucleotide-Binding Oligomerization Domain-Containing Protein 1 (NOD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430272
tested applications
P-ELISA, WB
Description
NOD1 Antibody is a Goat Polyclonal antibody against NOD1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Nucleotide-Binding Oligomerization Domain-Containing Protein 1 (NOD1) Immunogen: abx269142 - C-Terminus: EAKVYEDEKRIICF |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 10392 |
| NCBI Accession | NP_006083.1 |
| Alias | CARD4, CLR7.1, NLRC1, nucleotide binding oligomerization domain containing 1 |
| Background | Antibody anti-NOD1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
NOD1 (Nucleotide-binding Oligomerization Domain Containing 1) is an intracellular protein involved in the immune response, particularly in the recognition of bacterial pathogens. It is a member of the NOD-like receptor (NLR) family and plays a crucial role in activating innate immunity. NOD1 detects specific bacterial peptidoglycan fragments, triggering a signaling cascade that leads to the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and other inflammatory pathways. This process results in the production of pro-inflammatory cytokines that help recruit immune cells to the site of infection. NOD1's role in inflammation also links it to various diseases, including inflammatory bowel disease (IBD), atherosclerosis, and other conditions where immune system dysregulation is evident. NOD1 has also been implicated in cancer biology due to its influence on tumor-promoting inflammatory responses.
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