Nucleoporin 50 (NUP50) Antibody
312€ (60 µl)
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Name
Nucleoporin 50 (NUP50) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx123832
Tested Applications
WB, IHC
Description
NUP50 Antibody is a Rabbit Polyclonal Antibody against NUP50.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nucleoporin 50 (NUP50) Immunogen: Recombinant fusion protein corresponding to human NUP50 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 46 kDa/50 kDa Observed MW: 50 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKX7 |
| Gene ID | 10762 |
| NCBI Accession | NP_009103.2 |
| Alias | NPAP60,NPAP60L,nucleoporin 50kDa,Nuclear pore-associated protein 60 kDa-like |
| Background | Antibody anti-NUP50 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nucleoporin 50 (NUP50) is another key nucleoporin involved in the transport of proteins and RNA across the nuclear envelope NUP50 functions as a shuttle protein in the process of nuclear import, facilitating the recycling of importin proteins, which are required for the delivery of cargo molecules into the nucleus It is involved in the release of cargo from importins at the nuclear pore and aids in the efficient transport of proteins involved in various cellular processes such as signal transduction, gene regulation, and DNA repair NUP50’s role in nuclear import is crucial for maintaining cellular function, as defects in this process can lead to impaired gene expression, cell cycle progression, and protein localization Dysregulation of NUP50 has been implicated in diseases such as cancer, where alterations in nuclear import and protein trafficking contribute to tumor progression and metastasis
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