Nucleic Acid Dioxygenase ALKBH1 (ALKBH1) Antibody
169€ (20 µl)
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Name
Nucleic Acid Dioxygenase ALKBH1 (ALKBH1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx320102
Tested Applications
ELISA, IHC
Description
ALKBH1 Antibody is a Rabbit Polyclonal against ALKBH1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nucleic Acid Dioxygenase ALKBH1 (ALKBH1) Immunogen: Recombinant human Alkylated DNA repair protein alkB homolog 1 protein (110-389AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13686 |
| Gene ID | 8846 |
| OMIM | 605345 |
| Alias | ALKBH1,ABH,ABH1,ALKBH |
| Background | Antibody anti-ALKBH1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALKBH1 is an alpha-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase that functions in DNA and RNA repair, as well as histone demethylation. ALKBH1 removes methyl adducts, such as N3-methylcytosine (m3C) and N1-methyladenine (m1A), from nucleic acids, restoring their normal structure and preventing mutagenesis. Beyond its role in DNA and RNA repair, ALKBH1 acts as a histone H2A dioxygenase, regulating chromatin structure and gene expression through histone demethylation. It influences transcription, cellular differentiation, and embryonic development by modulating histone methylation marks. ALKBH1 has been implicated in cellular responses to oxidative and alkylating damage, as it counteracts methylation stress caused by environmental toxins or chemotherapeutic agents. Dysregulation of ALKBH1 is associated with cancer, where aberrant repair or histone demethylation may contribute to tumor progression, genomic instability, and drug resistance. ALKBH1 also plays a role in metabolic reprogramming by linking α-KG metabolism to epigenetic regulation.
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