Nucleic Acid Dioxygenase ALKBH1 (ALKBH1) Antibody
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Description
ALKBH1 Antibody is a Rabbit Polyclonal against ALKBH1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nucleic Acid Dioxygenase ALKBH1 (ALKBH1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13686 |
| Gene ID | 8846 |
| OMIM | 605345 |
| Alias | ALKBH1,ABH,ABH1,ALKBH |
| Background | Antibody anti-ALKBH1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ALKBH1 is an alpha-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase that functions in DNA and RNA repair, as well as histone demethylation. ALKBH1 removes methyl adducts, such as N3-methylcytosine (m3C) and N1-methyladenine (m1A), from nucleic acids, restoring their normal structure and preventing mutagenesis. Beyond its role in DNA and RNA repair, ALKBH1 acts as a histone H2A dioxygenase, regulating chromatin structure and gene expression through histone demethylation. It influences transcription, cellular differentiation, and embryonic development by modulating histone methylation marks. ALKBH1 has been implicated in cellular responses to oxidative and alkylating damage, as it counteracts methylation stress caused by environmental toxins or chemotherapeutic agents. Dysregulation of ALKBH1 is associated with cancer, where aberrant repair or histone demethylation may contribute to tumor progression, genomic instability, and drug resistance. ALKBH1 also plays a role in metabolic reprogramming by linking α-KG metabolism to epigenetic regulation.
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