Nucleic Acid Dioxygenase ALKBH1 (ALKBH1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
ALKBH1 Antibody is a Rabbit Polyclonal against ALKBH1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nucleic Acid Dioxygenase ALKBH1 (ALKBH1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13686 |
| Gene ID | 8846 |
| Alias | ALKBH1,ABH,ABH1,ALKBH |
| Background | Antibody anti-ALKBH1 |
| Status | RUO |
Descripción
ALKBH1 is an alpha-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase that functions in DNA and RNA repair, as well as histone demethylation. ALKBH1 removes methyl adducts, such as N3-methylcytosine (m3C) and N1-methyladenine (m1A), from nucleic acids, restoring their normal structure and preventing mutagenesis. Beyond its role in DNA and RNA repair, ALKBH1 acts as a histone H2A dioxygenase, regulating chromatin structure and gene expression through histone demethylation. It influences transcription, cellular differentiation, and embryonic development by modulating histone methylation marks. ALKBH1 has been implicated in cellular responses to oxidative and alkylating damage, as it counteracts methylation stress caused by environmental toxins or chemotherapeutic agents. Dysregulation of ALKBH1 is associated with cancer, where aberrant repair or histone demethylation may contribute to tumor progression, genomic instability, and drug resistance. ALKBH1 also plays a role in metabolic reprogramming by linking α-KG metabolism to epigenetic regulation.
Related Products
anti- ALKBH1 antibody
Dioxygenase that acts as a DNA demethylase(PubMed:18603530). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:18603530). Specifically demethylates DNA methylated on the 6th position of adenine(N(6)-methyladenosine) DNA. N(6)-methyladenosine(m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing(By similarity). Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation, but with low activity(PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites(PubMed:19959401). DNA lyase activity does not require alpha-ketoglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product(PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation(By similarity).
Ver Producto
Nucleic Acid Dioxygenase ALKBH1 (ALKBH1) Antibody
Rabbit Polyclonal against the ALKBH1 protein.
Ver ProductoNucleic Acid Dioxygenase ALKBH1 (ALKBH1) Antibody
Alkb, Alkylation Repair Homolog 1 (E. Coli) Antibody is a Rabbit Polyclonal antibody against Alkb, Alkylation Repair Homolog 1 (E. Coli).
Ver Producto