Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) Antibody
357.5€ (100 µg)
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935106861
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name
Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037382
tested applications
ELISA, IHC
Description
Rabbit Polyclonal against the NR3C1 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_001020825 |
| Alias | GR,GCR,GRL,GCCR,GCRST,Glucocorticoid receptor |
| Background | Antibody anti-NR3C1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
Nuclear receptor subfamily 3 group C member 1 (NR3C1), also known as the glucocorticoid receptor (GR), is a nuclear receptor that mediates the effects of glucocorticoids, hormones involved in stress response, metabolism, and immune function NR3C1 is activated by glucocorticoids, such as cortisol, and regulates the expression of genes involved in inflammation, immune suppression, and metabolism It is expressed in a variety of tissues, including the liver, immune cells, and brain, where it influences processes such as glucose metabolism, fat storage, and the immune response NR3C1 plays a key role in the body’s response to stress by regulating the hypothalamic-pituitary-adrenal (HPA) axis, which controls the production of cortisol and other stress hormones Dysregulation of NR3C1 signaling has been linked to various diseases, including metabolic syndrome, depression, autoimmune disorders, and cancer, where improper glucocorticoid signaling can contribute to inflammation, altered metabolism, and immune dysfunction GR is also a target for corticosteroid drugs used to treat conditions like asthma, arthritis, and autoimmune diseases
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