Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1) Antibody
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Description
NR0B1 Antibody is a Goat Polyclonal antibody against NR0B1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 190 |
| NCBI Accession | NP_000466.2 |
| Alias | AHC,AHX,DSS,GTD,HHG,AHCH,DAX1,DAX-1,NROB1,SRXY2,Nuclear receptor DAX-1,DSS-AHC critical region on the X chromosome protein 1 |
| Background | Antibody anti-NR0B1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Nuclear receptor subfamily 0 group B member 1 (NR0B1), also known as DAX-1, is a nuclear receptor that plays a crucial role in the regulation of endocrine function, particularly in the development and function of the gonads and adrenal glands NR0B1 acts as a transcriptional regulator by binding to DNA and influencing the expression of target genes involved in steroidogenesis, sexual differentiation, and reproductive function It functions primarily by repressing the activity of other nuclear receptors, such as steroid hormone receptors, and plays a key role in controlling the balance of sex hormones and their effects on the body NR0B1 is essential for the proper development of the hypothalamic-pituitary-gonadal axis, and mutations in the NR0B1 gene have been associated with disorders such as 46, XY gonadal dysgenesis, a condition that results in underdeveloped gonads and infertility Additionally, NR0B1 is involved in regulating the development of the central nervous system and the regulation of bone metabolism Dysregulation of NR0B1 has been linked to several endocrine disorders and cancers
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