Nuclear receptor ROR-gamma (RORC) Antibody
221€ (50 µg)
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Name
Nuclear receptor ROR-gamma (RORC) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx325610
Tested Applications
ELISA, WB
Description
RORC Antibody is a Rabbit Polyclonal against RORC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nuclear receptor ROR-gamma (RORC) Immunogen: Synthesized peptide derived from the Internal region of human RORγ. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51449 |
| Gene ID | 6097 |
| Alias | TOR,RORG,RZRG,IMD42,NR1F, RZR-GAMMA,Nuclear receptor ROR-gamma,RAR-related orphan receptor C,Nuclear receptor subfamily 1 group F member 3 |
| Background | Antibody anti-RORC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAR related orphan receptor C (RORC), also known as RORγ, is a nuclear receptor that plays a crucial role in regulating immune responses, particularly in the differentiation of Th17 cells, which are a subset of helper T cells involved in autoimmune diseases RORC is essential for the regulation of inflammatory processes and the production of pro-inflammatory cytokines, making it a key player in the pathogenesis of conditions like rheumatoid arthritis, psoriasis, and multiple sclerosis RORC also influences the development of the thymus and other immune organs, playing a role in maintaining immune homeostasis It is involved in the regulation of metabolic processes and the response to oxidative stress and environmental factors Dysregulation of RORC expression is linked to autoimmune diseases, chronic inflammation, and cancer, where altered immune regulation contributes to disease progression Targeting RORC with specific inhibitors has been explored as a therapeutic strategy to manage autoimmune diseases and inflammatory conditions, highlighting its potential as a drug target in immune-related therapies
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