Nuclear Factor Kappa B p65 Phospho-Ser536 (NFkB p65 pS536) Antibody

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Nuclear Factor Kappa B p65 Phospho-Ser536 (NFkB p65 pS536) Antibody is a Rabbit Polyclonal antibody against NFkB p65 (pSer536). This antibody detects NFkB p65 phosphorylated at residue(s) Ser536.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Nuclear Factor Kappa B p65 Phospho-Ser536 (NFkB p65 pS536) |
Host | Rabbit |
Reactivity | Human |
Assay Data | Modification: Phosphorylation // Target Modification: Ser536 |
Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified |
Size 1 | 50 µg |
Form | Liquid |
Tested Applications | ELISA, WB, IHC |
Buffer | PBS. Contains sodium azide. |
Availability | Shipped within 3-7 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q04206 |
Background | Antibody anti-NFkB |
Status | RUO |
Note | Concentration: 0.5 mg/ml - |
Descripción
Related Products

NFkB p65 Antibody
Transcription factors of the nuclear factor kappa B (NF- kappa B)/Rel family is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. There are five family members in mammals: RelA (p65), c-Rel, RelB, NF- kappa B1 (p105/p50) and NF- kappa B2 (p100/p52). The most studied NF- kappa B complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF- kappa B with its inhibitor, I kappa B. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to I kappa B. This complex prevents nuclear translocation and activity of NF- kappa B. In response to stimuli such as cytokines, LPS, and viral infections, I kappa B is phosphorylated at critical residues. This phosphorylation induces dissociation of the I kappa B/NF- kappa B complex, allowing the free heterodimeric NF- kappa B to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the kappa B site within promoters and enhancers and functions as a transcriptional activator.
Ver Producto
NFkB p65 (Phospho-Ser281) Antibody
Rabbit polyclonal antibody against NF- kappa B p65 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:S281, M:S281, R:S281.
Ver Producto
NFkB p65 Antibody
Rabbit polyclonal antibody against NF- kappa B p65 protein. Immunogen region is Internal.
Ver Producto