Nuclear Factor Kappa B (NFkB) Antibody

Product Graph
299€ (100 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Nuclear Factor Kappa B (NFkB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx132774
tested applications
WB, IHC, IF/ICC

Description

Nuclear Factor Kappa B (NFkB) Antibody is a Rabbit Polyclonal antibody for the detection of Nuclear Factor Kappa B (NFkB).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Nuclear Factor Kappa B (NFkB)
Host
Rabbit
Reactivity
Zebrafish
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Background
Antibody anti-NFkB
Status
RUO
Note
Concentration: 500 µg/ml -

Descripción

Related Products

abx012273

NFkB p65 Antibody

Transcription factors of the nuclear factor kappa B (NF- kappa B)/Rel family is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. There are five family members in mammals: RelA (p65), c-Rel, RelB, NF- kappa B1 (p105/p50) and NF- kappa B2 (p100/p52). The most studied NF- kappa B complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF- kappa B with its inhibitor, I kappa B. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to I kappa B. This complex prevents nuclear translocation and activity of NF- kappa B. In response to stimuli such as cytokines, LPS, and viral infections, I kappa B is phosphorylated at critical residues. This phosphorylation induces dissociation of the I kappa B/NF- kappa B complex, allowing the free heterodimeric NF- kappa B to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the kappa B site within promoters and enhancers and functions as a transcriptional activator.

Ver Producto
abx012581

NFkB p65 (Phospho-Ser281) Antibody

Rabbit polyclonal antibody against NF- kappa B p65 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:S281, M:S281, R:S281.

Ver Producto
abx012874

NFkB p65 Antibody

Rabbit polyclonal antibody against NF- kappa B p65 protein. Immunogen region is Internal.

Ver Producto