Notch Homolog 2 Cleaved-Ala1734 (NOTCH2 Cleaved-A1734) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Notch Homolog 2 Cleaved-Ala1734 (NOTCH2 Cleaved-A1734) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx216915
tested applications
ELISA, WB, IHC
Description
Notch Homolog 2 Cleaved-Ala1734 (NOTCH2 Cleaved-A1734) Antibody is a Rabbit Polyclonal antibody for the detection of NOTCH2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Notch Homolog 2 Cleaved-Ala1734 (NOTCH2 Cleaved-A1734) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q04721 |
| Gene ID | 4853 |
| OMIM | 102500 |
| Alias | AGS2,HJCYS,hN2,notch receptor 2 |
| Background | Antibody anti-NOTCH2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
NOTCH2 is a key receptor in the Notch signaling pathway that regulates cell proliferation, differentiation, and tissue patterning during development. Ligand binding induces proteolytic cleavage, releasing the NOTCH2 intracellular domain (NICD), which activates transcription of target genes to control cell fate decisions. NOTCH2 is particularly critical for organogenesis, including kidney development, where it regulates nephron formation and podocyte differentiation. Dysregulation of NOTCH2 is linked to various pathologies, including Alagille syndrome, where mutations impair liver, heart, and kidney development. NOTCH2 also plays a role in cancer, where aberrant signaling promotes tumorigenesis, particularly in breast, pancreatic, and biliary tract cancers. Knockout models demonstrate defects in kidney morphogenesis, osteoclast development, and hematopoiesis, highlighting NOTCH2’s essential role in organ development, cellular differentiation, and disease progression.
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